Can anti-cholinergics cause dementia?
Virginia Thornley, M.D., Neurologist, Epileptologist
July 1, 2019
In one study, they found that anti-cholinergic agents shows an increased risk of dementia. In the study, certain anti-depressants and urologic agents were found to correlate more with the risk of dementia including dosulepine, duloxetine and amitriptyline for the anti-depressants and tolteridine and oxybutinin for the urologic agents (1).
There are thoughts that there is a risk of dementia even 2 decades after the exposure. Certain anti-Parkinson’s agents were found to possible correlate with dementia. Anti-cholinergic agents have consistently been associated with problems with short-term memory.
1.Richardson, K., Fox, C., Maidment, I, Steel, N., Loke, Y, Arthur, A., Myint, P., Grossi, C., Mattishent, K., Bennett, K., Campbell, N., Boustani, M., Robinson, L., Brayne, C., Matthews, F., Savva, G. Anti-cholinergic drugs and risk of dementia: case-control study, BMJ, 2018; 361